p70S6K/Akt inhibitor M-2698

{
  "id": "MLC-T-ONC-015756",
  "term": "p70S6K/Akt inhibitor M-2698",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. Upon administration, p70S6K/Akt inhibitor M-2698 binds to and inhibits the activity of p70S6K and Akt. This prevents the activation of the PI3K/Akt/p70S6K signaling pathway and inhibits tumor cell proliferation in cancer cells that have an overactivated PI3K/Akt/p70S6K signaling pathway. Constitutive activation and dysregulated signaling of the PI3K/Akt/p70S6K pathway are frequently associated with tumorigenesis of many tumor types; targeting multiple kinases in this pathway is more efficacious than targeting a single kinase.",
  "synonyms": [
    "p70S6K/Akt inhibitor MSC2363318A"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/p70s6k-akt-inhibitor-m-2698/"
}