Bisantrene hydrochloride

{
  "id": "MLC-T-ONC-012027",
  "term": "Bisantrene hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the helical structure of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.",
  "synonyms": [
    "orange crush",
    "bisantrene dihydrochloride"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bisantrene-hydrochloride/"
}