Mitoxantrone hydrochloride

{
  "id": "MLC-T-ONC-005426",
  "term": "Mitoxantrone hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with other drugs to treat acute myeloid leukemia in adults, advanced prostate cancer that did not get better with hormone therapy, and certain forms of multiple sclerosis. It is also being studied in the treatment of other types of cancer. Mitoxantrone hydrochloride damages the cell’s DNA and may kill cancer cells. It also blocks a certain enzyme needed for cell division and DNA repair. Mitoxantrone hydrochloride may also stop certain immune cells from causing damage to the brain and spinal cord. It is a type of antineoplastic antibiotic and a type of topoisomerase inhibitor.",
    "The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin."
  ],
  "abbreviation": "DHAD",
  "synonyms": [
    "dihydroxyanthracenedione",
    "mitoxantrone HCl",
    "mitoxantrone dihydrochloride",
    "dihydroxyanthracenedione dihydrochloride",
    "mitozantrone",
    "mitoxantroni hydrochloridum",
    "mitozantrone hydrochloride"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mitoxantrone-hydrochloride/"
}