Mivavotinib

{
  "id": "MLC-T-ONC-015209",
  "term": "Mivavotinib",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Spleen tyrosine kinase inhibitor mivavotinib may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation, differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies.",
  "synonyms": [
    "syk Inhibitor TAK-659",
    "Spleen Tyrosine Kinase Inhibitor TAK659",
    "syk-Inhibitor TAK-659"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mivavotinib/"
}