entospletinib

{
  "id": "MLC-T-ONC-013370",
  "term": "entospletinib",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity. Upon oral administration of entospletinib, this agent may inhibit the activity of Syk, which inhibits B-cell receptor (BCR) signaling and leads to an inhibition of tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues and is often overexpressed in hematopoeitic malignancies.",
  "synonyms": [
    "spleen tyrosine kinase inhibitor GS-9973",
    "SYK inhibitor GS-9973",
    "ENTO"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/entospletinib/"
}