Fostamatinib disodium

{
  "id": "MLC-T-ONC-003330",
  "term": "Fostamatinib disodium",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat thrombocytopenia (a low blood platelet count) in adults with chronic immune thrombocytopenia (ITP) that did not get better with other treatment. ITP is a condition in which platelets are destroyed by the immune system. Fostamatinib disodium is also being studied in the treatment of other conditions and types of cancer. It blocks an enzyme called Syk, which may help keep the immune system from destroying platelets. Fostamatinib disodium is a type of tyrosine kinase inhibitor. Also called R788 sodium, Syk kinase inhibitor R-935788, and Tavalisse.",
    "An orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis."
  ],
  "synonyms": [
    "R788 sodium",
    "Syk kinase inhibitor R-935788",
    "Tavalisse",
    "SYK kinase inhibitor R935788",
    "fostamatinib disodium hexahydrate",
    "R-935788 sodium"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fostamatinib-disodium/"
}