fostriecin

{
  "id": "MLC-T-ONC-013770",
  "term": "fostriecin",
  "field": "Oncology and biomedicine",
  "definition": "An anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis in various malignant cell types. This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation.",
  "abbreviation": "FST",
  "synonyms": [
    "phosphotrienin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fostriecin/"
}