Bizaxofusp

{
  "id": "MLC-T-ONC-012052",
  "term": "Bizaxofusp",
  "field": "Oncology and biomedicine",
  "definition": "A fusion protein consisting of the cytokine interleukin-4 (IL-4) linked to a truncated form of Pseudomonas exotoxin with potential antineoplastic activity. Upon specific, high-affinity binding to IL-4 receptors located on the tumor cell surface., bizaxofusp is internalized; the exotoxin moiety then binds to translation elongation factor 2 (EF-2), which may result in ADP ribosylation, deactivation of EF-2, inhibition of protein synthesis, and tumor cell apoptosis. The Pseudomonas exotoxin moiety of this agent has been engineered to reduce non-specific binding to cells expressing its receptor, the multiligand cell surface receptor alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein (alpha 2MR/LRP). IL-4R is a type I transmembrane protein that binds IL-4 and IL-13 and may be overexpressed by cancers such as renal cell carcinoma and glioma.",
  "abbreviation": "IL4-PE",
  "synonyms": [
    "interleukin-4 PE38kdel immunotoxin",
    "interleukin-4 fusion toxin",
    "IL-4 fusion toxin",
    "interleukin-4 Pseudomonas exotoxin",
    "IL4-Pseudomonas exotoxin fusion protein MDNA55"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bizaxofusp/"
}