anti-EGP-2 immunotoxin MOC31-PE

{
  "id": "MLC-T-ONC-010624",
  "term": "anti-EGP-2 immunotoxin MOC31-PE",
  "field": "Oncology and biomedicine",
  "definition": "An immunotoxin consisting of a monoclonal antibody directed against epithelial glycoprotein-2 (EP-2, or epithelial cell adhesion molecule (EpCAM)) conjugated to the bacterial toxin Pseudomonas exotoxin A (PE) with potential antineoplastic activity. Upon administration of anti-EGP-2 immunotoxin MOC31-PE, the monoclonal antibody moiety targets and binds to EP-2. Upon internalization, the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in EP-2-expressing cells. EP-2, a tumor-associated antigen, is overexpressed in a variety of cancer cell types.",
  "synonyms": [
    "anti-epithelial glycoprotein-2 immunotoxin MOC31-PE"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egp-2-immunotoxin-moc31-pe/"
}