TGFa-PE38 immunotoxin

{
  "id": "MLC-T-ONC-017097",
  "term": "TGFa-PE38 immunotoxin",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding domain. The TGF-alpha moiety of the agent attaches to tumor cells expressing the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.",
  "abbreviation": "TP-38",
  "synonyms": [
    "TP-38"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tgfa-pe38-immunotoxin/"
}