LMB-9 immunotoxin

{
  "id": "MLC-T-ONC-004889",
  "term": "LMB-9 immunotoxin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A toxic substance linked to an antibody that attaches to tumor cells and kills them.",
    "A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis."
  ],
  "synonyms": [
    "LMB-9",
    "B3 (dsFv)-PE38"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lmb-9-immunotoxin/"
}