LMB-1 immunotoxin

{
  "id": "MLC-T-ONC-004886",
  "term": "LMB-1 immunotoxin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A toxic substance linked to an antibody that attaches to tumor cells and kills them.",
    "A chimeric protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of Pseudomonas exotoxin A without its cell-binding region. LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors. The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2."
  ],
  "abbreviation": "LMB-1",
  "synonyms": [
    "immunotoxin LMB-1",
    "B3-NLysPE38"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lmb-1-immunotoxin/"
}