L-lysine/L-arginine-containing amino acid solution

{
  "id": "MLC-T-ONC-014861",
  "term": "L-lysine/L-arginine-containing amino acid solution",
  "field": "Oncology and biomedicine",
  "definition": "An intravenous (IV) amino acid (AA) solution containing the cationic amino acids L-lysine and L-arginine, with radioprotective activity. Upon IV administration of the AA solution, L-lysine and L-arginine are specifically taken up by the kidneys. This protects the kidneys from toxicity by certain co-administered radio-labeled peptides as they compete with radio-labeled peptides for renal uptake. This reduces uptake of the radio-labeled peptides by the kidneys and decreases their renal retention. It also increases the target-to-kidney ratio of the radio-labeled peptides, thereby reducing radiation exposure to the kidneys and preventing nephrotoxicity.",
  "synonyms": [
    "radioprotective amino acid solution",
    "L-lysine/L-arginine AA solution",
    "intravenous L-lysine/L-arginine-containing amino acid solution",
    "amino acid solution-containing L-lysine and L-arginine",
    "amino acid renal protectant solution"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/l-lysine-l-arginine-containing-amino-acid-solution/"
}