BL22 immunotoxin

{
  "id": "MLC-T-ONC-001096",
  "term": "BL22 immunotoxin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A bacterial toxic substance linked to an antibody that attaches to cancer cells and kills them. It belongs to the family of drugs called bacterial immunotoxins.",
    "A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells."
  ],
  "abbreviation": "BL22",
  "synonyms": [
    "BL22",
    "RFB4(dsFv)-PE38 immunotoxin",
    "BL22 Immunotoxin [RFB4(dsFv)-PE38]",
    "anti-CD22 recombinant immunotoxin BL22"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bl22-immunotoxin/"
}