LMB-7 immunotoxin

{
  "id": "MLC-T-ONC-004888",
  "term": "LMB-7 immunotoxin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A toxic substance linked to an antibody that attaches to tumor cells and kills them.",
    "A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2."
  ],
  "synonyms": [
    "immunotoxin LMB-7",
    "B3(Fv)-PE38 Immunotoxin",
    "B3(Fv)-PE38",
    "HB21(Fv)PE40",
    "LMB-7 (Single-Chain Immunotoxin)"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lmb-7-immunotoxin/"
}