erb-38 immunotoxin

{
  "id": "MLC-T-ONC-002937",
  "term": "erb-38 immunotoxin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A toxic substance linked to an antibody that attaches to tumor cells and kills them.",
    "A bivalent fusion protein consisting of disulfide-stabilized Fv fragments of an anti-HER2 (erbB2) monoclonal antibody (e23) and a truncated version of the M(r) 38 fragment of Pseudomonas exotoxin that lacks the toxin's cell binding domain. ERB-38 immunotoxin binds specifically to cells that overexpress HER2, the antigenic target of the monoclonal antibody; the exotoxin portion of the immunotoxin then lyses the cells bound by the antibody portion."
  ],
  "synonyms": [
    "erb-38"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/erb-38-immunotoxin/"
}