LMB-2 immunotoxin

{
  "id": "MLC-T-ONC-004887",
  "term": "LMB-2 immunotoxin",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A toxic substance linked to an antibody that attaches to tumor cells and kills them.",
    "A fusion protein consisting of the Fv portion of a monoclonal antibody attached to a 38-kDa fragment of the Pseudomonas exotoxin A (with amino acids 365-380 deleted). LMB-2 immunotoxin targets the interleukin 2 receptor (also known as IL-2R or CD25) which is expressed on activated normal T and B cells and macrophages and on the cells of various hematologic malignancies. The antibody attaches to the IL-2R on the cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis."
  ],
  "abbreviation": "LMB-2",
  "synonyms": [
    "Anti-Tac(Fv)-PE38",
    "LMB-2 (anti-TAC(FV)-PE-38)",
    "humanized antiTac toxin|"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lmb-2-immunotoxin/"
}