TGFbDNRII-transduced autologous tumor-infiltrating lymphocytes

{
  "id": "MLC-T-ONC-017098",
  "term": "TGFbDNRII-transduced autologous tumor-infiltrating lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of tumor infiltrating lymphocytes (TILs) that are transduced with a retroviral vector encoding a gene for a dominant-negative form of the transforming growth factor beta (TGFb) receptor, TGFbDNRII, with potential immunomodulating activity. Upon administration, the TGFbDNRII-transduced autologous TILs recognize and kill tumor cells. The expression of TGFbDNRII allows for the TILs to be resistant to TGF-b-mediated inhibition of T cell proliferation and activation, which allows optimal TIL activity. The immunosuppressant TGF-b is produced by tumor cells and plays a key role in the repression of the immune system.",
  "synonyms": [
    "TGFbDNRII-transduced autologous TILs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tgfbdnrii-transduced-autologous-tumor-infiltrating-lymphocytes/"
}