TGFbeta inhibitor LY3200882

{
  "id": "MLC-T-ONC-017099",
  "term": "TGFbeta inhibitor LY3200882",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable agent that targets transforming growth factor-beta (TGFb), with potential antineoplastic activity. Upon administration, LY3200882 specifically targets and binds to TGFb, which prevents both the binding of TGFb to its receptor TGFbR and TGFb-mediated signal transduction. This may lead to a reduction in TGFb-dependent proliferation of cancer cells. The TGFb signaling pathway is often deregulated in tumors, and plays a key role in the regulation of cell growth, differentiation, apoptosis, motility, invasion, angiogenesis, and various immune responses.",
  "synonyms": [
    "TGFb inhibitor LY 3200882"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tgfbeta-inhibitor-ly3200882/"
}