CXCR2-transduced autologous tumor infiltrating lymphocytes

{
  "id": "MLC-T-ONC-012846",
  "term": "CXCR2-transduced autologous tumor infiltrating lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor infiltrating lymphocytes (TILs) that are transduced, ex vivo, with a retroviral vector encoding a gene for CXC chemokine receptor 2 (CXCR2), with potential antineoplastic activity. Upon administration of the CXCR2-transduced autologous TILs, the CXCR2-expressing T cells selectively migrate toward tumor cells expressing CXCR2 ligands, which leads to tumor cell killing. CXCR2 expression allows for optimal TIL migration towards tumor cells and enhances the TILs anti-tumor activity. This leads to a reduction in both tumor cell proliferation and survival. CXCR2, a transmembrane protein also known as IL-8 receptor B (IL-8RB), plays a key role in inflammation and cancer progression. Certain CXCR2 ligands, such as CXCL1 and CXCL8 (IL-8), are expressed by tumor cells.",
  "synonyms": [
    "CXCR2-transduced autologous TILs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cxcr2-transduced-autologous-tumor-infiltrating-lymphocytes/"
}