anti-mucin-1/PE immunoconjugate BM7PE

{
  "id": "MLC-T-ONC-010909",
  "term": "anti-mucin-1/PE immunoconjugate BM7PE",
  "field": "Oncology and biomedicine",
  "definition": "An immunoconjugate containing BM7, a murine monoclonal antibody directed against the human tumor-associated antigen (TAA) mucin-1 (MUC1; MUC-1) covalently linked to the bacterial toxin Pseudomonas exotoxin A (PE), with potential antitumor activity. Upon administration of BM7PE, the antibody moiety targets and binds to MUC1. In turn, the PE moiety inhibits protein synthesis via modifying translation elongation factor 2 (EF-2), thereby causing apoptosis and inhibiting tumor cell growth and proliferation in MUC1-overexressing cancer cells. MUC1, a type I transmembrane protein, is overexpressed in a variety of tumor types. It plays an important role in cancer progression and metastasis.",
  "synonyms": [
    "immunotoxin BM7PE",
    "anti-MUC1/PE BM7PE"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-mucin-1-pe-immunoconjugate-bm7pe/"
}