anti-mucin-1/CD16A bispecific antibody BGB-B3227

{
  "id": "MLC-T-ONC-010908",
  "term": "anti-mucin-1/CD16A bispecific antibody BGB-B3227",
  "field": "Oncology and biomedicine",
  "definition": "An immunoglobulin G1 (IgG1) humanized bispecific antibody directed against the tumor associated antigen (TAA) mucin-1 (MUC1) and the human low affinity IgG Fc region receptor IIIA (FCGR3A; CD16A), with potential immunomodulating and antineoplastic activities. Upon administration, anti-MUC1/CD16A bispecific antibody BGB-B3227 targets and binds to CD16A expressed on natural killer (NK) cells and MUC1 expressed on the surface of tumor cells, thereby selectively cross-linking tumor and NK cells. This may result in NK cell activation and eventually tumor cell lysis. CD16A is specifically expressed on the surface of NK cells. MUC1, a glycoprotein overexpressed on the surface of a variety of cancer cells, plays a key role in tumor cell survival and proliferation.",
  "synonyms": [
    "anti-Muc1 NK cell engager BGB-B3227",
    "anti-MUC1/CD16A bispecific antibody BGB-B3227",
    "anti-mucin-1/anti-CD16A bispecific antibody BGB-B3227",
    "MUC1 x CD16A bispecific antibody BGB-B3227"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-mucin-1-cd16a-bispecific-antibody-bgb-b3227/"
}