anti-EGFR/CD16A bispecific antibody AFM24

{
  "id": "MLC-T-ONC-010603",
  "term": "anti-EGFR/CD16A bispecific antibody AFM24",
  "field": "Oncology and biomedicine",
  "definition": "A human, tetravalent, bispecific antibody targeting both the epidermal growth factor receptor (EGFR) and the human low affinity IgG Fc region receptor IIIA (FCGR3A; CD16A), with potential immunomodulating and antineoplastic activities. Upon administration, anti-EGFR/CD16A bispecific antibody AFM24 simultaneously targets and binds to the CD16A expressed on natural killer (NK) cells and macrophages, and to EGFR on EGFR-expressing tumor cells, thereby selectively cross-linking EGFR-expressing tumor cells with NK cells and macrophages. This may result in NK cell and macrophage activation, antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and eventually tumor cell lysis. EGFR, a receptor tyrosine kinase upregulated or mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. CD16A is specifically expressed on the surface of NK cells and macrophages.",
  "synonyms": [
    "anti-EGFR/anti-CD16A bispecific antibody AFM24",
    "anti-EGFR/CD16A tetravalent bispecific antibody AFM24",
    "bispecific EGFR/CD16A innate cell engager AFM24"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfr-cd16a-bispecific-antibody-afm24/"
}