marlotamig

{
  "id": "MLC-T-ONC-015011",
  "term": "marlotamig",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody directed against both human epidermal growth factor receptor (EGFR) and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration of marlotamig, this bispecific antibody binds to both CD28 on cytotoxic T lymphocytes (CTLs) and EGFR found on EGFR-expressing tumor cells. This activates and redirects CTLs to EGFR-expressing tumor cells, which may result in the CTL-mediated cell death of EGFR-expressing tumor cells. EGFR, a member of the epidermal growth factor receptor family, is overexpressed on various tumor cell types.",
  "synonyms": [
    "EGFR x CD28 bispecific antibody REGN7075"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/marlotamig/"
}