boronophenylalanine-fructose complex

{
  "id": "MLC-T-ONC-001182",
  "term": "boronophenylalanine-fructose complex",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance used in a type of radiation therapy called boron neutron capture therapy. Boronophenylalanine-fructose complex is injected into a blood vessel and collects in tumor cells. The patient then receives radiation therapy with atomic particles called neutrons. The neutrons react with the boron in boronophenylalanine-fructose complex, producing radioactive particles that kill the tumor cells without harming normal cells. Also called BPA-F.",
    "A boronated phenylalanine complexed with fructose to increase its solubility. When exposed to neutron irradiation, boronophenylalanine absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells, known as boron neutron capture therapy (BNCT), spares adjacent normal tissues."
  ],
  "abbreviation": "BPA-F",
  "synonyms": [
    "BPA-F",
    "p-Boronophenylalanine-Fructose Complex"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/boronophenylalanine-fructose-complex/"
}