boron-dipyrromethene-modified olaparib fluorescent imaging agent

{
  "id": "MLC-T-ONC-012070",
  "term": "boron-dipyrromethene-modified olaparib fluorescent imaging agent",
  "field": "Oncology and biomedicine",
  "definition": "A poly (ADP-ribose) polymerase type 1 (PARP1) fluorescence imaging agent based on the PARP1 inhibitor olaparib, in which the cyclopropane group of olaparib is replaced by the green fluorescent dye boron-dipyrromethene (BODIPY) fluorophore (FL), with potential fluorescent imaging activity. Upon administration of the fluorescent PARP1 inhibitor PARPi-FL, the olaparib binding moiety specifically targets and binds to PARP1, which is often overexpressed on cancer cells. Upon fluorescent imaging, the PARP1-expressing cancer cells can be visualized. PARP1, the nuclear enzyme that catalyzes post-translational ADP-ribosylation of nuclear proteins, is activated by single-strand (SS) DNA breaks and overexpressed in certain tumor cells; it plays a key role in DNA repair, tumor cell resistance and survival.",
  "abbreviation": "PARPi-FL",
  "synonyms": [
    "fluorescent PARPi binding imaging agent PARPi-FL",
    "olaparib-BODIPY FL",
    "fluorescent PARP1 inhibitor PARPi-FL",
    "AZD2281-BODIPY FL",
    "BODIPY-modified olaparib fluorescent imaging agent"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/boron-dipyrromethene-modified-olaparib-fluorescent-imaging-agent/"
}