Fluorine F 18 fluorthanatrace

{
  "id": "MLC-T-ONC-013680",
  "term": "Fluorine F 18 fluorthanatrace",
  "field": "Oncology and biomedicine",
  "definition": "A radiotracer consisting of an analogue of the poly(ADP-ribose) polymerase 1 (PARP1) inhibitor rucaparib radiolabeled with the positron emitting isotope fluorine F 18, which can potentially be used for the imaging of PARP1 expression using positron emission tomography (PET). Upon administration, fluorine F 18 fluorthanatrace targets and binds to PARP1. Upon PET, PARP1-expressing tumor cells can be visualized. PARP1, which is overexpressed in many cancer cell types, catalyzes post-translational ADP-ribosylation of nuclear proteins and plays a key role in the repair of DNA strand breaks.",
  "abbreviation": "[18F]FTT",
  "synonyms": [
    "[18F]FluorThanatrace"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-fluorthanatrace/"
}