Carbon C 11 AZ14193391

{
  "id": "MLC-T-ONC-012247",
  "term": "Carbon C 11 AZ14193391",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of AZ14193391, a central nervous system (CNS) penetrant and selective inhibitor of nuclear enzyme poly(ADP-ribose) polymerase (PARP) 1, labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET). Upon administration, carbon C 11 AZ14193391 specifically targets and binds to PARP1. Upon PET imaging, this radioligand may allow for the assessment of PARP1 expression in tumors and visualization of AZ14193391. PARP1 catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and plays a key role in the repair of single strand DNA (ssDNA) breaks and double-strand breaks (DSBs).",
  "synonyms": [
    "11C-AZ14193391",
    "[11C]AZ14193391"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c-11-az14193391/"
}