carbon C 11 YJH08

{
  "id": "MLC-T-ONC-012258",
  "term": "carbon C 11 YJH08",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of YJH08, a synthetic glucocorticoid receptor (GR) agonist, labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET). Upon intravenous administration of carbon C 11 YJH08, the YJH08 moiety targets and binds to GR on tumor cells. Upon PET imaging, this radioligand may allow for the assessment of GR-expressing tumor cells. This also allows assessment of YJH08's pharmacokinetic profile and affinity of GR-positive tumor cells. The GR, a member of the nuclear receptor superfamily of ligand-dependent transcription factors, is overexpressed in certain tumor types and may be associated with tumor cell proliferation and treatment resistance.",
  "synonyms": [
    "11C YJH08",
    "[11C]-5-(4-fluorobenzyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f ]-quinoline",
    "11C-YJH08",
    "[11C] YJH08"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c-11-yjh08/"
}