carbon C 11 methylaminoisobutyrate

{
  "id": "MLC-T-ONC-012252",
  "term": "carbon C 11 methylaminoisobutyrate",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic neutral amino acid analog radiolabeled with carbon C 11 with potential use for metabolic tumor imaging during positron emission tomography (PET). Upon administration, carbon C 11 methylaminoisobutyrate ([(11)C]MeAIB) is taken up by and accumulates in cancer cells through the A-type (alanine-preferring) amino acid transport system. Upon imaging of the radioisotope, the distribution patterns of MeAIB and its uptake by cancer cells can be further elucidated. This may establish its usefulness as a tumor tracer in the diagnosis of certain cancers. Amino acid transport system A is highly upregulated in malignant cells and facilitates the uptake of amino acids needed for tumor cell proliferation.",
  "abbreviation": "11C-MeAIB",
  "synonyms": [
    "N-methyl-11C-methylaminoisobutylric acid",
    "N-methyl-11C-methylaminoisobutyric acid"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c-11-methylaminoisobutyrate/"
}