Carbon C 11 martinostat

{
  "id": "MLC-T-ONC-012250",
  "term": "Carbon C 11 martinostat",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of martinostat, a histone deacetylase (HDAC) inhibitor, labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET)/magnetic resonance imaging (MRI). Upon intravenous administration of carbon C 11 martinostat, the martinostat moiety targets and binds to HDAC on tumor cells. Upon PET/MRI imaging, this radioligand may allow for the assessment of HDAC-expressing tumor cells. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.",
  "synonyms": [
    "[11C]martinostat",
    "martinostat C-11",
    "[11C]-metformin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c-11-martinostat/"
}