Carbon C 11-osimertinib

{
  "id": "MLC-T-ONC-012260",
  "term": "Carbon C 11-osimertinib",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of osimertinib, a third-generation, orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, labeled with the positron-emitting isotope carbon C 11, with potential use in imaging via positron emission tomography (PET). Upon intravenous administration of carbon C 11 osimertinib, the osimertinib targets and binds to mutant forms of EGFR on tumor cells. Upon PET imaging, this radioligand may allow for the assessment of EGFR mutant-expressing tumor cells. This also allows assessment of osimetinib’s pharmacokinetic profile and affinity of EGFR mutant-positive cancer cells and may identify patients who may respond well to osimertinib.",
  "synonyms": [
    "[11C] osimertinib",
    "11C-osimertinib",
    "[11C]AZD9291"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c-11-osimertinib/"
}