fluorine F 18 PARP inhibitor

{
  "id": "MLC-T-ONC-013692",
  "term": "fluorine F 18 PARP inhibitor",
  "field": "Oncology and biomedicine",
  "definition": "A radiotracer consisting of a 1(2H)phthalazinone-based poly(ADP-ribose) polymerase 1 (PARP1) inhibitor radiolabeled with the positron emitting isotope fluorine F 18, which can potentially be used for the imaging of PARP1 expression using positron emission tomography (PET). Upon administration, fluorine F 18 PARPi targets and binds to PARP1. Upon PET, PARP1-expressing tumor cells can be visualized. PARP1, which is overexpressed in many cancer cell types, catalyzes post-translational ADP-ribosylation of nuclear proteins and plays a key role in the repair of DNA strand breaks.",
  "synonyms": [
    "fluorine F 18 PARPi",
    "fluorine F 18 poly(ADP-ribose) polymerase inhibitor",
    "[18F]PARPi",
    "[18F]PARPi imaging agent",
    "[18F]PARP1-targeted probe",
    "18F fluorinated PARP1-targeted probe",
    "18F-1(2H)phthalazinone-based PARPi imaging agent",
    "18F-radiolabeled 1(2H)phthalazinone PARPi"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fluorine-f-18-parp-inhibitor/"
}