capecitabine

{
  "id": "MLC-T-ONC-001384",
  "term": "capecitabine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with other drugs to treat certain types of colorectal cancer, breast cancer, esophageal cancer, gastroesophageal junction cancer, stomach cancer, and pancreatic cancer. It is also being studied in the treatment of other types of cancer. Capecitabine is taken up by cancer cells and breaks down into fluorouracil, a substance that kills cancer cells. Capecitabine is a type of antimetabolite. Also called Xeloda.",
    "A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand."
  ],
  "abbreviation": "CAPE",
  "synonyms": [
    "Xeloda"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/capecitabine/"
}