Carbon C 13 dextromethorphan

{
  "id": "MLC-T-ONC-012262",
  "term": "Carbon C 13 dextromethorphan",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of dextromethorphan, a synthetic, methylated dextrorotatory analogue of levorphanol, conjugated with carbon-13 [(13)C] with radiotracer activity. (13)C-dextromethorphan can be used in a breath-test phenotype assay of CYP2D6 activity, based on the principle that CYP2D6-mediated O-demethylation cleaves a (13)CH3 that enters the body's carbon pool to be eliminated ultimately as (13)CO2 in expired air, which can be measured. The (13)C-dextromethorphan breath test may prove useful in identifying poor CYP2D6 metabolizers of such important clinical drugs as tamoxifen.",
  "abbreviation": "13C-dextromethorphan",
  "synonyms": [
    "Carbon C-13 Dextromethorphan"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carbon-c-13-dextromethorphan/"
}