Carvedilol phosphate extended-release capsule

{
  "id": "MLC-T-ONC-012325",
  "term": "Carvedilol phosphate extended-release capsule",
  "field": "Oncology and biomedicine",
  "definition": "An extended-release capsule formulation containing the phosphate salt of carvedilol, a nonselective beta-adrenergic blocking agent with alpha 1-adrenergic blocking activity. Carvedilol is a racemic mixture; the S(-) enantiomer non-selectively binds to and blocks beta-adrenergic receptors, exerting negative inotropic and chronotropic effects, leading to a reduction in cardiac output. Both R(+) and S(-) enantiomers bind to and block alpha 1-adrenergic receptors with equal potency, causing vasodilation and a reduction in peripheral vascular resistance. This agent has no intrinsic sympathomimetic activity.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carvedilol-phosphate-extended-release-capsule/"
}