Cathepsin-targeted fluorescent imaging probe VGT-309

{
  "id": "MLC-T-ONC-012336",
  "term": "Cathepsin-targeted fluorescent imaging probe VGT-309",
  "field": "Oncology and biomedicine",
  "definition": "A fluorescently quenched, cathepsin-activatable, near infrared (NIR) probe containing the dye indocyanine green (ICG), that may be used for cancer imaging purposes using an NIR imaging system. Upon administration, cathepsin-targeted fluorescent imaging probe VGT-309 covalently and irreversibly binds to cathepsins overexpressed by tumor cells. This displaces the quencher QC-1 and activates the ICG fluorophore. Upon NIR imaging, cathepsin-expressing tumor cells can be detected which allows for visualization of the tumor.",
  "synonyms": [
    "cathepsin-targeted fluorescent imaging agent VGT-309",
    "cathepsin-activatable fluorescent imaging agent VGT-309"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cathepsin-targeted-fluorescent-imaging-probe-vgt-309/"
}