CD122-selective IL-2/Anti-CD25 antibody-like fusion protein ANV419

{
  "id": "MLC-T-ONC-012359",
  "term": "CD122-selective IL-2/Anti-CD25 antibody-like fusion protein ANV419",
  "field": "Oncology and biomedicine",
  "definition": "A formulation consisting of lipid nanoparticles (LNPs) encapsulating nucleoside-modified messenger RNA (mRNA) encoding the endogenous cytokine interleukin-2 (IL-2), with potential immunostimulating activity. Upon administration, ribocytokine IL-2 BNT153 is taken up by cells and the expressed IL-2 targets and binds to the IL-2 receptor beta subunit (IL2Rb; IL2Rbeta; CD122). The binding of IL-2 to IL2Rb activates IL2Rb-mediated signaling, which activates cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells, and induces expression of certain cytotoxic cytokines, such as interferon-gamma (IFNg) and transforming growth factor-beta (TGFb). The specific induction of T-cell-mediated cytotoxic immune responses against tumor cells causes tumor cell destruction. IL2Rb plays a key role in the proliferation and activation of effector T-cells.",
  "synonyms": [
    "antibody-like fusion protein ANV419",
    "CD122-selective IL-2/anti-IL-2Ra antibody fusion protein ANV419"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd122-selective-il-2-anti-cd25-antibody-like-fusion-protein-anv419/"
}