CD200 activation receptor ligand hP1A8

{
  "id": "MLC-T-ONC-012386",
  "term": "CD200 activation receptor ligand hP1A8",
  "field": "Oncology and biomedicine",
  "definition": "A humanized peptide ligand of the CD200 activation receptors (CD200ARs), with potential immunostimulating and antineoplastic activities. Upon administration, CD200 activation receptor ligand (CD200AR-L) human P1A8 (hP1A8) targets and binds to CD200ARs complexes on antigen-presenting cells (APCs). This promotes immature dendritic cell (DC) differentiation and cytokine production, and induces a T-cell-mediated immune response against tumor cells. In addition, hP1A8 downregulates the expression of the inhibitory CD200 and PD-1 receptors on APCs and T cells. This inhibits CD200- and PD-1-mediated immunosuppression. CD200, a type 1a transmembrane protein related to the B7 family of co-stimulatory receptors, functions as an immune checkpoint that modulates immune responses through an inhibitory receptor CD200 receptor 1 (CD200R1) and several activation receptors (CD200ARs). It plays an important role in tumor evasion from host immunity.",
  "synonyms": [
    "CD200AR-L hP1A8"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd200-activation-receptor-ligand-hp1a8/"
}