CDK2 inhibitor NKT3447

{
  "id": "MLC-T-ONC-012446",
  "term": "CDK2 inhibitor NKT3447",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential antineoplastic activity. Upon oral administration, CDK2 inhibitor NKT3447 selectively targets, reversibly binds to and inhibits the activity of CDK2. This blocks G1/S cell cycle transition, which leads to cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. CDK2, a serine/threonine kinase that plays an important role in the regulation of cell cycle progression and cellular proliferation, is overexpressed in certain tumor cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cdk2-inhibitor-nkt3447/"
}