CEA/tetanus toxoid T helper epitope fusion protein-expressing DNA plasmid vaccine

{
  "id": "MLC-T-ONC-012484",
  "term": "CEA/tetanus toxoid T helper epitope fusion protein-expressing DNA plasmid vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A plasmid vaccine encoding wild type human carcinoembryonic antigen (CEA) fused to a tetanus toxoid T helper epitope, with potential antineoplastic activity. Upon vaccination and subsequent intradermal electroporation, CEA/tetanus toxoid T helper epitope fusion protein-expressing DNA plasmid vaccine may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. CEA, a tumor associated antigen, is overexpressed in a variety of cancer cell types. The tetanus toxoid helper peptide epitope, obtained from the bacterial Clostridium tetani toxoid, binds to class II MHC molecules and increases the helper T-cell response thereby inducing an increased and long-term immune response.",
  "abbreviation": "tetwtCEA DNA",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cea-tetanus-toxoid-t-helper-epitope-fusion-protein-expressing-dna-plasmid/"
}