Ceftazidime/avibactam sodium

{
  "id": "MLC-T-ONC-012501",
  "term": "Ceftazidime/avibactam sodium",
  "field": "Oncology and biomedicine",
  "definition": "A combination preparation containing the third-generation cephalosporin ceftazidime and the sodium salt form of avibactam, a non-beta-lactam beta-lactamase inhibitor, with antibiotic and beta-lactamase inhibiting activity, respectively. Upon administration, ceftazidime binds to essential penicillin-binding proteins (PBPs) and inhibits cell wall synthesis in certain bacteria. Avibactam binds to and inactivates beta-lactamases, thereby protecting ceftazidime from degradation and increasing ceftazidime’s efficacy.",
  "synonyms": [
    "ceftazidime-avibactam sodium",
    "CAZ-AVI"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ceftazidime-avibactam-sodium/"
}