choline kinase alpha inhibitor TCD-717

{
  "id": "MLC-T-ONC-012582",
  "term": "choline kinase alpha inhibitor TCD-717",
  "field": "Oncology and biomedicine",
  "definition": "A small-molecule inhibitor of choline kinase alpha (CHKA), with potential antineoplastic activity. TCD-717 targets and binds to CHKA, an enzyme that plays a key role in the synthesis of phosphatidylcholine, the major phospholipid in eukaryotic cell membranes. Blockade of this enzyme induces cells to activate a different route for phospholipid production which causes a toxic effect and eventually leads to cell destruction. CHKA, overexpressed in human cancer cells while only minimally expressed in normal cells, appears to play a significant role in cellular proliferation, evasion of apoptosis, increased cell motility and metastasis.",
  "abbreviation": "CHKA inhibitor TCD-717",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/choline-kinase-alpha-inhibitor-tcd-717/"
}