corticorelin acetate

{
  "id": "MLC-T-ONC-012778",
  "term": "corticorelin acetate",
  "field": "Oncology and biomedicine",
  "definition": "The acetate salt form of coticorelin, a synthetic peptide of neurohormone corticotropin-releasing factor (CRF), with potential antitumor and antiangiogenesis activities. Upon administration, corticorelin stimulates adrenocorticotropic hormone (ACTH) secretion from the anterior pituitary gland. In turn, ACTH stimulates cortisol production from the adrenal cortex and is regulated by a negative feedback mechanism. Corticorelin appears to inhibit swelling around brain tumors through reduction in vascular leakage and maintenance of endothelial cell integrity. This agent potentially suppresses vascularization and tumor cell growth through reduction of vascular endothelial growth factor (VEGF) that appears to be via activation of corticotrophin-releasing factor receptor 2 (CRFR2), a G protein-coupled receptor.",
  "synonyms": [
    "hCRF",
    "corticorelin",
    "corticoliberin",
    "synthetic human corticotropin-releasing factor",
    "recombinant human corticotropin releasing factor",
    "human corticotropin-releasing factor"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/corticorelin-acetate/"
}