Cositecan

{
  "id": "MLC-T-ONC-012784",
  "term": "Cositecan",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Cositecan stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, cositecan exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins.",
  "synonyms": [
    "karenitecin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cositecan/"
}