COX-2 inhibitor ECP-1014

{
  "id": "MLC-T-ONC-012789",
  "term": "COX-2 inhibitor ECP-1014",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the enzyme cyclooxygenase-2 (COX-2), with potential analgesic, anti-inflammatory and antineoplastic activities. Upon oral administration, COX-2 inhibitor ECP-1014 inhibits COX-2, thereby inhibiting the conversion of arachidonic acid to prostaglandins, including prostaglandin E2 (PGE2). This may reduce pain and inflammation. The COX-2/PGE 2 pathway may also play an important role in tumor proliferation, angiogenesis, metastasis and immune suppression in the tumor microenvironment (TME). COX-2 is overexpressed in certain tumor cells.",
  "synonyms": [
    "cyclooxygenase-2 inhibitor ECP-1014"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cox-2-inhibitor-ecp-1014/"
}