CSF1R inhibitor HMPL-653

{
  "id": "MLC-T-ONC-012820",
  "term": "CSF1R inhibitor HMPL-653",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF1R; CSF-1R; CD115; M-CSFR), with potential immunomodulatory and antineoplastic activities. Upon oral administration, CSF1R inhibitor HMPL-653 targets and binds to CSF1R, thereby blocking CSF1R activation and CSF1R-mediated signaling. This inhibits the activities of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), and prevents immune suppression in the tumor microenvironment (TME). This enhances antitumor T-cell immune responses and inhibits the proliferation of tumor cells. CSF1R, also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface receptor that plays major roles in tumor cell proliferation and metastasis.",
  "synonyms": [
    "colony-stimulating factor 1 receptor inhibitor HMPL-653",
    "CSF-1R inhibitor HMPL-653"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/csf1r-inhibitor-hmpl-653/"
}