darbepoetin alfa

{
  "id": "MLC-T-ONC-002283",
  "term": "darbepoetin alfa",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat anemia caused by chronic kidney disease and some types of chemotherapy. Darbepoetin alfa is a form of erythropoietin (a substance naturally made by the kidneys) that is made in the laboratory. It helps the bone marrow make more red blood cells. Darbepoetin alfa is a type of antianemic and a type of erythropoiesis-stimulating agent. Also called Aranesp.",
    "A recombinant analog of the endogenous cytokine erythropoietin, an erythropoiesis-stimulating protein. Due to the addition of two carbohydrate chains, darbepoetin alfa exhibits a three-fold greater half-life than does erythropoietin. Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and maturation of erythrocyte progenitors, stimulating endothelial cell proliferation, and stimulating B-cell proliferation and immunoglobulin production."
  ],
  "abbreviation": "NESP",
  "synonyms": [
    "Aranesp",
    "Novel Erythropoiesis Stimulating Protein"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/darbepoetin-alfa/"
}