deficient DNA mismatch repair

{
  "id": "MLC-T-ONC-002335",
  "term": "deficient DNA mismatch repair",
  "field": "Oncology and biomedicine",
  "definition": "Describes cells that have mutations (changes) in certain genes that are involved in correcting mistakes made when DNA is copied in a cell. DNA mismatch repair (MMR) deficient cells usually have many DNA mutations, which may lead to cancer. DNA MMR deficiency is most common in colorectal cancer, other types of gastrointestinal cancer, and endometrial cancer, but it may also be found in cancers of the breast, prostate, bladder, and thyroid and in an inherited disorder called Lynch syndrome. Knowing if a tumor is DNA MMR deficient may help plan treatment or predict how well the tumor will respond to treatment. Also called deficient mismatch repair, dMMR, mismatch repair deficiency, and MMR deficiency.",
  "synonyms": [
    "deficient mismatch repair",
    "dMMR",
    "mismatch repair deficiency",
    "MMR deficiency"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/deficient-dna-mismatch-repair/"
}