Dexrazoxane hydrochloride

{
  "id": "MLC-T-ONC-002395",
  "term": "Dexrazoxane hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat severe side effects caused by certain types of anticancer drugs. It is used under the brand names Totect and Zinecard to reduce heart damage in women who are receiving doxorubicin for breast cancer that has spread to other parts of the body. It is also used under the brand name Totect to treat the toxic effects of an anticancer drug that leaks from a vein into surrounding tissue and causes tissue damage. Dexrazoxane hydrochloride is also being studied in the treatment of some types of cancer. It is a type of cardioprotective agent, a type of chemoprotective agent, and a type of topoisomerase inhibitor. Dexrazoxane is the active ingredient of dexrazoxane hydrochloride.",
    "The hydrochloride salt of a bisdioxopiperazine with iron-chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical-generating anthracycline-iron complexes, which may minimize anthracycline-iron complex-mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the catalytic activity of topoisomerase II, which may result in tumor cell growth inhibition."
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dexrazoxane-hydrochloride/"
}